[cleanairuk_news] Health Effects of Air Quality and Noise - update February 2018

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* Health Effects of Air Quality and Noise - update February 2018 *

By Barbara Rimmington, Researcher, East End Quality of Life Initiative

(Previous edition - January 2018:  
http://cleanairuk.org/pipermail/news_cleanairuk.org/2018-March/000122.html)

(Index for previous issues:  
http://www.cleanairuk.org/health-air-pollution.html)

*CONTENTS*

1) Periconception Exposure to Air Pollution and Risk of Congenital  
Malformations

2) Asthma prevalence and school-related hazardous air pollutants in  
the US-Mexico border area

3) Long-term high air pollution exposure induced metabolic adaptations  
in traffic policemen

4) Respiratory and cardiovascular responses to walking down a  
traffic-polluted road compared with walking in a traffic-free area in  
participants aged 60 years and older with chronic lung or heart  
disease and age-matched healthy controls: a randomised, crossover study

5) The health impacts of weekday traffic: A health risk assessment of  
PM2.5 emissions during congested periods

6) Air Pollution and Performance-Based Physical Functioning in Dutch  
Older Adults

7) Differential Susceptibility in Ambient Particle-Related First-Ever  
Stroke Onset Risk: Findings From a National Case-Crossover Study

8) Short-term exposure to traffic-related air pollution and ischemic  
stroke onset in Barcelona, Spain

9) Short-term effects of ultrafine particles on daily mortality by  
primary vehicle exhaust versus secondary origin in three Spanish cities

10) Ambient Air Pollution and Chronic Bronchitis in a Cohort of U.S. Women

11) Sperm DNA fragmentation: An early and reliable marker of air pollution

12) Long-term Air Pollution Exposure, Genome-wide DNA Methylation and  
Lung Function in the LifeLines Cohort Study

13) Short-term particulate matter exposure influences nasal microbiota  
in a population of healthy subjects

14) Long-Term Exposure to Fine Particulate Matter, Blood Pressure, and  
Incident Hypertension in Taiwanese Adults

15) Fine Particulate Air Pollution and the Expression of microRNAs and  
Circulating Cytokines Relevant to Inflammation, Coagulation, and  
Vasoconstriction

16) Mortality risks from a spectrum of causes associated with  
wide-ranging exposure to fine particulate matter: A case-crossover  
study in Beijing, China

17) Estimated effects of air pollution and space-time-activity on  
cardiopulmonary outcomes in healthy adults: A repeated measures study

18) Associations between long-term PM2.5 and ozone exposure and  
mortality in the Canadian Census Health and Environment Cohort  
(CANCHEC), by spatial synoptic classification zone

19) Concentrated Ambient PM2.5-Induced Inflammation and Endothelial  
Dysfunction in a Murine Model of Neural IKK2 Deficiency

20) Causality test of ambient fine particles and human influenza in  
Taiwan: Age group-specific disparity and geographic heterogeneity

21) Assessment of long-term exposure to airborne dioxin and cadmium  
concentrations in the Lyon metropolitan area (France)

22) Ambient air pollution, adipokines, and glucose homeostasis: The  
Framingham Heart Study

23) Reflectance spectroscopy: a novel approach to better understand  
and monitor the impact of air pollution on Mediterranean plants

- o -

1) Periconception Exposure to Air Pollution and Risk of Congenital  
Malformations

Sheng Ren, Erin Haynes, Eric Hall, Monir Hossain, Aimin Chen, Louis  
Muglia, Long Lu, Emily DeFranco

Increased exposure to PM2.5 in the periconception period is associated  
with some modest risk increases for congenital malformations. The most  
susceptible time of exposure appears to be the 1 month before and  
after conception. Although the increased risk with PM2.5 exposure is  
modest, the potential impact on a population basis is noteworthy  
because all pregnant women have some degree of exposure.

Journal of Pediatrics 193 76-84.e6 - read article  
(http://www.jpeds.com/article/S0022-3476(17)31330-6/fulltext)

- o -

2) Asthma prevalence and school-related hazardous air pollutants in  
the US-Mexico border area

Genny Carrillo, Maria J.Perez Patron, Natalie Johnson, Yan Zhong, Rose  
Lucio, Xiaohui Xu

Complex mixtures have been linked with respiratory symptoms. Asthma  
screenings will help to identify those children with high risk of  
asthma. There is a potential association between air toxics exposure  
and asthma in children.

Environmental Research 162, April 2018, 41-48 - read article  
(https://doi.org/10.1016/j.envres.2017.11.057)

- o -

3) Long-term high air pollution exposure induced metabolic adaptations  
in traffic policemen

Chaochao Tan, Yupeng Wang, Mingyue Lin, Zhu Wang, Li He, Zhiyi Li, Yu  
Li, Keqian Xu

Fasting blood glucose and cancer embryo antigen increased and  
positively correlated with cumulative intersection duty time.  
High-density lipoprotein cholesterol decreased and negatively  
correlated with cumulative intersection duty time in traffic  
policemen. These findings provided evidences for the association  
between long-term PM2.5 exposure and the Type 2 diabetes and  
cardiovascular diseases.

Environmental Toxicology and Pharmacology 58, March 2018, 156-162 -  
read abstract (https://doi.org/10.1016/j.etap.2018.01.002)

- o -

4) Respiratory and cardiovascular responses to walking down a  
traffic-polluted road compared with walking in a traffic-free area in  
participants aged 60 years and older with chronic lung or heart  
disease and age-matched healthy controls: a randomised, crossover study

Rudy Sinharay, Jicheng Gong, Benjamin Barratt, Pamela  
Ohman-Strickland, Sabine Ernst, Frank J Kelly, Junfeng (Jim) Zhang,  
Peter Collins, Paul Cullinan, Kian Fan Chung,

Short-term exposure to traffic pollution prevents the beneficial  
cardiopulmonary effects of walking in people with COPD, ischaemic  
heart disease, and those free from chronic cardiopulmonary diseases.  
Medication use might reduce the adverse effects of air pollution in  
individuals with ischaemic heart disease. Policies should aim to  
control ambient levels of air pollution along busy streets in view of  
these negative health effects.

The Lancet 391:10118 339–349, 27 January 2018 - read article  
(https://doi.org/10.1016/S0140-6736(17)32643-0)

- o -

5) The health impacts of weekday traffic: A health risk assessment of  
PM2.5 emissions during congested periods

Weeberb J.Requia, Christopher D.Higgins, Matthew D.Adams, Moataz  
Mohamed, Petros Koutrakis

Traffic congestion has a substantial impact on human health and  
economy. Our results showed an impact of 206 (95%: 116; 297) deaths  
per year (all-cause mortality). Our results showed an impact of 119  
(95%: 67; 171) deaths per year (cardiovascular mortality).

Environment International 111, February 2018, 164-176 - read abstract  
(https://doi.org/10.1016/j.envint.2017.11.025)

- o -

6) Air Pollution and Performance-Based Physical Functioning in Dutch  
Older Adults

Femke de Zwart, Bert Brunekreef, Erik Timmermans, Dorly Deeg, Ulrike Gehring

This study suggests that exposure to air pollution may adversely  
affect physical performance of older adults in the Netherlands.

Environ Health Perspect; DOI:10.1289/EHP2239 - read article  
(https://doi.org/10.1289/EHP2239)

- o -

7) Differential Susceptibility in Ambient Particle-Related First-Ever  
Stroke Onset Risk: Findings From a National Case-Crossover Study

Tianjia Guan, Tao Xue, Yuanli Liu, Yixuan Zheng, Siyuan Fan, Kebin He,  
Qiang Zhang

We found that most of the CNSSS participants were at increased risk of  
PM2.5-related stroke, while only a small proportion were highly  
susceptible.

American Journal of Epidemiology January 2018 - read abstract  
(https://doi.org/10.1093/aje/kwy007)

- o -

8) Short-term exposure to traffic-related air pollution and ischemic  
stroke onset in Barcelona, Spain

Rosa Maria Vivanco-Hidalgo, Gregory A.Wellenius, Xavier Basagaña,  
Marta Cirach, Alejandra Gómez González, Pablo de Ceballos, Ana  
Zabalza, Jordi Jiménez-Conde, Carolina Soriano-Tarraga, Eva  
Giralt-Steinhauer, Andrés Alastuey, Xavier Querol, Jordi Sunyer,  
Jaume Roquer

BC levels are associated with higher risk of large-artery  
atherosclerosis stroke. This association did not vary by levels of  
green space and traffic noise. Setting BC air quality standards could  
have valuable health benefits.

Environmental Research 162, April 2018, 160-165 - read article  
(https://doi.org/10.1016/j.envres.2017.12.024)

- o -

9) Short-term effects of ultrafine particles on daily mortality by  
primary vehicle exhaust versus secondary origin in three Spanish cities

Aurelio TobÃas, Ioar Rivas, Cristina Reche, Andrés Alastuey, Sergio  
RodrÃguez, RocÃo Fernández-Camacho, Ana M.Sánchez de la Campa,  
Jesúsde la Rosa, Jordi Sunyer, Xavier Querol

Association between segregated components of UFP (N1 and N2) and daily  
mortality. BC is a better parameter to evaluate health effects of  
particulate vehicle exhaust emissions. Pattern and origin of UFP  
determines its short-term effect on daily mortality.

Environment International 111, February 2018, 144-151 - read abstract  
(https://doi.org/10.1016/j.envint.2017.11.015)

- o -

10) Ambient Air Pollution and Chronic Bronchitis in a Cohort of U.S. Women

Laura G. Hooper, Michael T. Young, Joshua P. Keller, Adam A. Szpiro,  
Katie M. O’Brien, Dale P. Sandler, Sverre Vedal, Joel D. Kaufman,  
Stephanie J. London

PM10 exposure was related to chronic bronchitis prevalence. Among  
never-smokers, PM2.5 and NO2 exposure was associated with chronic  
bronchitis and component symptoms. Results may have policy  
ramifications for PM10 regulation by providing evidence for  
respiratory health effects related to long-term PM10 exposure.

Environ Health Perspect; DOI:10.1289/EHP2199 - read article  
(https://doi.org/10.1289/EHP2199)

- o -

11) Sperm DNA fragmentation: An early and reliable marker of air pollution

Liana Bosco, Tiziana Notari, Giovanni Ruvolo, Maria C.Roccheri, Chiara  
Martino, Rosanna Chiappetta, Domenico Carone, Giosuè Lo Bosco, Laura  
Carrillo, Salvatore Raimondo, Antonino Guglielmino, Luigi Montano

Air pollution is a main risk factor for male infertility. Steel plant  
workers have higher sperm DNA Fragmentation Index (DFI) than controls.  
We propose sperm DFI as biomarker of presence and effects of polluted  
environment. We candidate human sperm as an early, sensitive biomarker  
of pollution.

Environmental Toxicology and Pharmacology 58, March 2018, 243-249 -  
read abstract (https://doi.org/10.1016/j.etap.2018.02.001)

- o -

12) Long-term Air Pollution Exposure, Genome-wide DNA Methylation and  
Lung Function in the LifeLines Cohort Study

Ana Julia de F.C. Lichtenfels, Diana A. van der Plaat, Kim de Jong,  
Cleo C. van Diemen, Dirkje S. Postma, Ivana Nedeljkovic, Cornelia M.  
van Duijn, Najaf Amin, Sacha la Bastide-van Gemert, Maaike de Vries,  
Cavin K. Ward-Caviness, Kathrin Wolf, Melanie Waldenberger, Annette  
Peters, Ronald P. Stolk, Bert Brunekreef, H. Marike Boezen, Judith M.  
Vonk

Long-term NO2 exposure was genome-wide significantly associated with  
DNA methylation in the identification cohort but not in the  
replication cohort. Future studies are needed to further elucidate the  
potential mechanisms underlying NO2–exposure–related respiratory  
disease.
Environ Health Perspect; DOI:10.1289/EHP2045 - read article  
(https://doi.org/10.1289/EHP2045)

- o -

13) Short-term particulate matter exposure influences nasal microbiota  
in a population of healthy subjects

Jacopo Mariani, Chiara Favero, Andrea Spinazzè, Domenico Maria  
Cavallo, Michele Carugno, Valeria Motta, Matteo Bonzini, Andrea  
Cattaneo, Angela Cecilia Pesatori, Valentina Bollati

We evaluated whether PM could induce a dysbiosis in the nasal  
microbiota. PM exposure reduces the diversity within the microbiota  
community. PM alters microbiota homeostasis potentially influencing  
disease development.

Environmental Research 162, April 2018, 119-126 - read abstract  
(https://doi.org/10.1016/j.envres.2017.12.016)

- o -

14) Long-Term Exposure to Fine Particulate Matter, Blood Pressure, and  
Incident Hypertension in Taiwanese Adults

Zilong Zhang, Cui Guo, Alexis K.H. Lau, Ta-Chien Chan, Yuan Chieh  
Chuang, Changqing Lin, Wun Kai Jiang, Eng-kiong Yeoh, Tony Tam, Kam S.  
Woo, Bryan P. Yan, Ly-yun Chang, Martin C.S. Wong, Xiang Qian Lao

Long-term exposure to PM2.5 air pollution is associated with higher  
blood pressure and an increased risk of hypertension. These findings  
reinforce the importance of air pollution mitigation strategies to  
reduce the risk of cardiovascular disease.

Environ Health Perspect; DOI:10.1289/EHP2466 - read article  
(https://doi.org/10.1289/EHP2466)

- o -

14) Daily exceedance concentration hours: A novel indicator to measure  
acute cardiovascular effects of PM2.5 in six Chinese subtropical cities

Hualiang Lin, Xiaojie Wang. Zhengmin (Min) Qian, Shu Guo, Zhenjiang  
Yao, Michael G.Vaughn, Guanghui Dong, Tao Liu, Jianpeng Xiao, Xing Li,  
Weilin Zeng, Yanjun Xu, Wenjun Ma

We created an indicator, daily excess concentration hours (DECH), in  
this study. DECH of PM2.5 was associated with cardiovascular mortality  
in six Chinese cities. DECH of PM2.5 might be a better indicator than  
daily mean concentration.

Environment International 111, February 2018, 117-123 - read abstract  
(https://doi.org/10.1016/j.envint.2017.11.022)

- o -

15) Fine Particulate Air Pollution and the Expression of microRNAs and  
Circulating Cytokines Relevant to Inflammation, Coagulation, and  
Vasoconstriction

Renjie Chen, Huichu Li, Jing Cai, Cuicui Wang, Zhijing Lin, Cong Liu,  
Yue Niu, Zhuohui Zhao, Weihua Li, Haidong Kan

Our findings require confirmation but suggest that effects of PM2.5 on  
cardiovascular diseases may be related to acute effects on cytokine  
expression, which may be partly mediated through effects of PM2.5 on  
miRNAs that regulate cytokine expression.

Environ Health Perspect; DOI:10.1289/EHP1447 - read article  
(https://doi.org/10.1289/EHP1447)

- o -

16) Mortality risks from a spectrum of causes associated with  
wide-ranging exposure to fine particulate matter: A case-crossover  
study in Beijing, China

Tiantian Li, Meilin Yan, Qinghua Sun, G. Brooke Anderson

The first study to investigate the associations between wide-ranging  
PM2.5 exposure and a range of causes of mortality. Elevated PM2.5  
associated with increased risks of all-cause, non-accidental,  
circulatory, respiratory and intentional self-harm mortality. Risks to  
specific causes of death were particularly clear for specific causes  
of circulatory mortality. A particularly noteworthy increase in risk  
for mortality caused by extrapyramidal and movement disorders.

Environment International 111, February 2018, 52-59 - read abstract  
(https://doi.org/10.1016/j.envint.2017.10.023)

- o -

17) Estimated effects of air pollution and space-time-activity on  
cardiopulmonary outcomes in healthy adults: A repeated measures study

Tom Cole-Hunter, Audrey de Nazelle, David Donaire-Gonzalez, Nadine  
Kubesch, Glòria Carrasco-Turigas, Florian Matt, Maria Forastera,  
Tania MartÃnez, Albert Ambros, Marta Cirach, David Martinez, Jordina  
Belmonte, Mark Nieuwenhuijsen

A repeated measures study of urban pollution effects on health is  
performed. Fifty-seven healthy adults repeat four measures of  
cardiopulmonary outcomes. Participant neighborhoods are assigned air  
pollution, noise and greenness values. Daily location-adjusted  
PMCoarse level significantly negatively associated with HRV. Annual  
residential O3 level significantly positively associated with  
diastolic BP.

Environment International 111, February 2018, 247-259 - read abstract  
(https://doi.org/10.1016/j.envint.2017.11.024)

- o -

18) Associations between long-term PM2.5 and ozone exposure and  
mortality in the Canadian Census Health and Environment Cohort  
(CANCHEC), by spatial synoptic classification zone

Sabit Cakmak, Chris Hebbern, Lauren Pinault, Eric Lavigne, Jennifer  
Vanos, Dan Lawson Crouse, Michael Tjepkema

We assign geographic zones in Canada based on SSC and identified 7  
climate zones. Lung cancer-related mortality risk due to long term  
exposure to PM2.5 varies by each climate zone in Canada. PM2.5 risk on  
lung cancer-related mortality remains significant after adjustment for  
ozone. The effect of ozone on lung cancer-related mortality was  
statistically non-significant.

Environment International 111, February 2018, 200-211 - read article  
(https://doi.org/10.1016/j.envint.2017.11.030)

- o -

19) Concentrated Ambient PM2.5-Induced Inflammation and Endothelial  
Dysfunction in a Murine Model of Neural IKK2 Deficiency

Minjie Chen, Xiaobo Qin, Lianglin Qiu, Sufang Chen, Huifen Zhou, Yanyi  
Xu, Ziying Hu, Yuhao Zhang, Qi Cao, Zhekang Ying

Our findings support a role of neural IKK2 in CAP exposure–induced  
local and systemic pro-inflammatory cytokine expression, pulmonary and  
adipose inflammation, and endothelial dysfunction, thus providing  
insight into pathophysiologic mechanisms that may mediate effects of  
PM2.5 exposure.

Environ Health Perspect; DOI:10.1289/EHP2311 - read article  
(https://doi.org/10.1289/EHP2311)

- o -

20) Causality test of ambient fine particles and human influenza in  
Taiwan: Age group-specific disparity and geographic heterogeneity

Cathy W.S.Chen, Ying-Hen Hsieh, Hung-Chie, Su, Jia Jing Wu

Modified Granger causality test examines influenza-PM2.5 causal  
relationship. Adult/elderly populations in southwest Taiwan are  
strongly affected by PM2.5. Utility of public transportation in Taipei  
might contribute to less health risk. Minimizing exposure to PM2.5 is  
important for persons prone to respiratory diseases.

Environment International 111, February 2018, 354-361 - read abstract  
(https://doi.org/10.1016/j.envint.2017.10.011)

- o -

21) Assessment of long-term exposure to airborne dioxin and cadmium  
concentrations in the Lyon metropolitan area (France)

T.Coudon, H.Hourani, C.Nguyen, E.Faure, F.R.Mancini, B.Ferversab, P.Salizzoni

We model the historical scenarios of cadmium and dioxin urban  
atmospheric pollution. Model results are tested against measurements  
of emissions and air concentrations. Results over 20 years show the  
effect of emission reduction on population exposure. Today, diffuse  
miscellaneous sources are the major dioxin air pollution contribution.  
For cadmium, the major air pollution contribution is due to  
traffic-related emissions.

Environment International 111, February 2018, 177-190 - read abstract  
(https://doi.org/10.1016/j.envint.2017.11.027)

- o -

22) Ambient air pollution, adipokines, and glucose homeostasis: The  
Framingham Heart Study

Wenyuan Li, Kirsten S.Dorans, Elissa H. Wilker, Mary B.Rice, Itai  
Kloog, Joel D.Schwartz, Petros Koutrakis, Brent A.Coull. Diane R.Gold,  
James B.Meigs, Caroline S.Fox, Murray A.Mittleman

Living closer to a major roadway was associated with higher fasting  
glucose. Annual average PM2.5 was not associated with measures of  
glucose homeostasis. Short-term exposure to BC and NOx were positively  
associated with fasting glucose. Short-term exposure to O3 was  
negatively associated with fasting glucose.

Environment International 111, February 2018, 14-22 - read abstract  
(https://doi.org/10.1016/j.envint.2017.11.010)

- o -

23) Reflectance spectroscopy: a novel approach to better understand  
and monitor the impact of air pollution on Mediterranean plants

Lorenzo Cotrozzi, Philip A. Townsend, Elisa Pellegrini, Cristina Nali,  
John J. Couture

Major emphasis should be placed on using vegetation spectroscopy for  
better understanding and monitoring the impact of air pollution on  
Mediterranean plants in the CC era.
Environ Sci Pollut Res (2017) - read abstract (https://doi.org/10.1007/s1135)


----------------------------------------------------------

Compiler and Editor: Barbara Rimmington, Researcher, East End Quality  
of Life Initiative

10 Montgomery Terrace Road

Sheffield S6 3BU

Tel. 0114 285 9931

Fax 0114 278 7173

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